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编 号:F349347
分子式:C15H14ClNOS
分子量:291.8
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1mg
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5mg
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生物活性:
Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain.

体内研究:
Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level.Animal Model:Male SpragueDawley rats (250 g) after paw incision surgery
Dosage:0.3 μg, 0.5 μg, 1 μg, and 3 μg
Administration:Intrathecal administration
Result:Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
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