产品
编 号：F349671
分子式：C12H15NO3
分子量：221.25
分子式：C12H15NO3
分子量：221.25
产品类型
规格
价格
是否有货
结构图
CAS No: 404009-40-1
产品详情
生物活性：
IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 μM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis.
体外研究：
IC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12.IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis.
IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 μM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis.
体外研究：
IC 86621 exhibits high selectivity against other kinases such as PI3K, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12.IC 86621 (0-100 nM, 24 h) protects RA (rheumatoid arthritis) T cells from apoptosis.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备