产品
编 号：F352338
分子式：C93H155N31O28S
分子量：2187.48
分子式：C93H155N31O28S
分子量：2187.48
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 412938-67-1
产品详情
生物活性：
Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research.
体内研究：
Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.Animal Model:Male C57Bl/6 mice
Dosage:0.1 nM, 1 nM
Administration:Intracerebroventricular (i.c.v.) injection
Result:Increased locomotor activity and promoted wakefulness.
体外研究：
Half-maximal effective concentrations (EC50) for mobilization of [Ca2+]i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively.Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC50 of6.7 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 nM).Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [125II] Y10-NPS,[125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 nM).
Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research.
体内研究：
Neuropeptide S human (0.1 nM-1 nM; i.c.v.) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.Animal Model:Male C57Bl/6 mice
Dosage:0.1 nM, 1 nM
Administration:Intracerebroventricular (i.c.v.) injection
Result:Increased locomotor activity and promoted wakefulness.
体外研究：
Half-maximal effective concentrations (EC50) for mobilization of [Ca2+]i are 9.4 nM, 3.2 nM, and 3.0 nM for human, rat, and mouse Neuropeptide S (NPS), respectively.Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC50 of6.7 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 nM).Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [125II] Y10-NPS,[125II] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 nM).
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