产品
编 号：F353552
分子式：C16H22O6
分子量：310.34
分子式：C16H22O6
分子量：310.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 41826-92-0
产品详情
生物活性：
Trepibutone (AA 149) increases secretion of bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract. Trepibutone can be used for the research of cholecystitis and functional gastrointestinal disorders.
体内研究：
Trepibutone (1-20 mg/kg; i.v. once) dose-dependently increases bile flow.Trepibutone (10 mg/kg; i.v. 3 h after 14C-erythritol injection) stimulates canalicular bile formation without enhancement of water secretion and inhibition of bile reabsorption in the biliary ductules and ducts.Animal Model:Anesthetized beagle dogs
Dosage:1-20 mg/kg
Administration:Intravenous injection; 1-20 mg/kg once
Result:Dose-dependently increased the bile flow of dogs and showed the peak increases of the bile flow with a dose of 10 mg/kg .
Animal Model:Beagle dogs with 14C-erythritol injection
Dosage:10 mg/kg
Administration:Intravenous injection; 10 mg/kg; 3 h after 14C-erythritol injection
Result:Increased the bile flow associated with canalicular bile flow and stimulated canalicular bile formation.
体外研究：
Trepibutone (1-1000 μM) markedly relaxes the sphincter of Oddi and duodenum.
Trepibutone (AA 149) increases secretion of bile and pancreatic juice, and accelerates flaccidity of the smooth muscle in the gastrointestinal tract. Trepibutone can be used for the research of cholecystitis and functional gastrointestinal disorders.
体内研究：
Trepibutone (1-20 mg/kg; i.v. once) dose-dependently increases bile flow.Trepibutone (10 mg/kg; i.v. 3 h after 14C-erythritol injection) stimulates canalicular bile formation without enhancement of water secretion and inhibition of bile reabsorption in the biliary ductules and ducts.Animal Model:Anesthetized beagle dogs
Dosage:1-20 mg/kg
Administration:Intravenous injection; 1-20 mg/kg once
Result:Dose-dependently increased the bile flow of dogs and showed the peak increases of the bile flow with a dose of 10 mg/kg .
Animal Model:Beagle dogs with 14C-erythritol injection
Dosage:10 mg/kg
Administration:Intravenous injection; 10 mg/kg; 3 h after 14C-erythritol injection
Result:Increased the bile flow associated with canalicular bile flow and stimulated canalicular bile formation.
体外研究：
Trepibutone (1-1000 μM) markedly relaxes the sphincter of Oddi and duodenum.
产品资料
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