产品
编 号：F355500
分子式：C20H22N2O
分子量：306.4
分子式：C20H22N2O
分子量：306.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 425399-05-9
产品详情
生物活性：
CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer.
体内研究：
CASIN (20 mg/kg; i.p. 2 times a day) prolongs lifetime of mice with busulfan injection.Animal Model:NSG mice with busulfan injection
Dosage:20 mg/kg
Administration:Intraperitoneal injection; 20 mg/kg 2 times a day
Result:Significantly prolonged the lifespan of xenografts mice better than bortezomib, and showed a leading position when combined with bortezomib.
体外研究：
CASIN (0-10 μM; 3 d) inhibits the growth of AMO-1, ARH-77, IM-9 , JJN-3, L-363, MOLP-8 and RPMI-8226/S cells.CASIN (0-10 μM; 16 h) inhibits melphalan induced FANCD2 mono-ubiquitination in LR5 cells but shows no effect to S cells.CASIN (5 μM; 2 d) increases cell apoptosis of bortezomib-resistant MM patient cells.
CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer.
体内研究：
CASIN (20 mg/kg; i.p. 2 times a day) prolongs lifetime of mice with busulfan injection.Animal Model:NSG mice with busulfan injection
Dosage:20 mg/kg
Administration:Intraperitoneal injection; 20 mg/kg 2 times a day
Result:Significantly prolonged the lifespan of xenografts mice better than bortezomib, and showed a leading position when combined with bortezomib.
体外研究：
CASIN (0-10 μM; 3 d) inhibits the growth of AMO-1, ARH-77, IM-9 , JJN-3, L-363, MOLP-8 and RPMI-8226/S cells.CASIN (0-10 μM; 16 h) inhibits melphalan induced FANCD2 mono-ubiquitination in LR5 cells but shows no effect to S cells.CASIN (5 μM; 2 d) increases cell apoptosis of bortezomib-resistant MM patient cells.
产品资料
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