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编 号：F358521
分子式：C19H21N
分子量：263.38
分子式：C19H21N
分子量：263.38
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CAS No: 438-60-8
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Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease.
体内研究：
Protriptyline (10 mg/kg; i.p.; for 21 days; rat model of AD) improves spatial learning and retention memory in STZ treated rats.Animal Model:Rat model of AD
Dosage:10 mg/kg
Administration:Intraperitoneal injection; for 21 days.
Result:Reduced pTau, Aβ42 and BACE-1 levels, neurodegeneration, oxidative stress and glial activation. Improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFκB and GFAP expression.
体外研究：
Protriptyline (0-70 μM; 24 hours; PC3 cells) causes cytotoxicity in PC3 cells.
Protriptyline is a potent antidepressant agent. Protriptyline inhibits AChE activity with IC50 value of 0.06 mM and inhibits Aβ Self-Assembly. Protriptyline can be used for depression and Alzheimers disease.
体内研究：
Protriptyline (10 mg/kg; i.p.; for 21 days; rat model of AD) improves spatial learning and retention memory in STZ treated rats.Animal Model:Rat model of AD
Dosage:10 mg/kg
Administration:Intraperitoneal injection; for 21 days.
Result:Reduced pTau, Aβ42 and BACE-1 levels, neurodegeneration, oxidative stress and glial activation. Improved p-ERK/ERK ratio and enhanced BDNF and CREB levels by reducing NFκB and GFAP expression.
体外研究：
Protriptyline (0-70 μM; 24 hours; PC3 cells) causes cytotoxicity in PC3 cells.
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