产品
编 号：F359388
分子式：C21H18N2O6
分子量：394.38
分子式：C21H18N2O6
分子量：394.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 442644-28-2
产品详情
生物活性：
JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth.
体外研究：
JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin.JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines.JW67 shows a concentrationdependent reduction in proliferation with a GI50 value of 7.8 μM.
JW67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM. JW67 affects the multiprotein complex consisting of β-catenin/GSK-3β/AXIN/APC/CK1 that rapidly reduces active β-catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth.
体外研究：
JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin.JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines.JW67 shows a concentrationdependent reduction in proliferation with a GI50 value of 7.8 μM.
产品资料
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