产品
编 号：F359477
分子式：C6H11NS2
分子量：161.29
分子式：C6H11NS2
分子量：161.29
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
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询价
结构图
CAS No: 4430-36-8
产品详情
生物活性：
Erucin (ERU) is an isothiocyanate particularly abundant in arugula. Erucin shows anticancer, neuroprotective, and anti-inflammatory activities.
体内研究：
Erucin (ERU) (0-300 nM) significantly inhibits TPA-induced edema formation.Erucin (30 μmol/kg; i.p.; twice a week for 4 week) shows neuroprotective effects.Animal Model:Female ICR mice (4 weeks of age), TPA (12-O-tetradecanoylphorbol-13-acetate)-induced mouse ear edema model
Dosage:0, 100, and 300 nM
Administration:Topically applied to the mouse ear 30 min prior to the topical application of TPA
Result:Significantly inhibited TPA-induced edema formation.
Animal Model:Male C57Bl/6 mice (9 weeks old, 25–30 g body weight)
Dosage:30 μmol/kg
Administration:Intraperitoneal administration, twice a week, 4 weeks (Induce brain lesion by intrastriatal injection of 6-OHDA)
Result:Induced a partial recovery in the rotational behavior test. Upregulated the expression of TH. Counteract neuronal death and DNA fragmentation in 6-OHDA lesioned mice. increase total GSH and Nrf2 levels in 6-OHDA lesioned mice.
体外研究：
Erucin (ERU) (0-100 μM) releases H2S and inhibits cell viability in AsPC‐1 cells in a concentration-dependent manner.Erucin inhibits cell migration and altered the AsPC‐1 cell cycle, reducing G0/G1 phase and increasing G2/M and S phases.Erucin (30 μM, 72 h) induces AsPC‐1 cell apoptosis and inhibits cell migration.Erucin reduces levels of phosphorylated ERK1/2 in AsPC‐1 cells.Erucin (0-200 μM, 24 h) shows antiproliferative activity with an IC50 of 97.7 μM in A549 cells. Erucin (0-50 μM, 24 h) induces the cleavage of PARP-1 at 50 μM, and increases p53 and p21 protein expression in A549 cells.Erucin decreases LPS-induced production of NO, prostaglandin E2 (PGE2), TNF-α, IL-6 and IL-1β in RAW 264.7 cells.Erucin decreases LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in RAW 264.7 cells.Erucin inhibits LPS-induced activation of NFκB Signaling in RAW 264.7 cells.
Erucin (ERU) is an isothiocyanate particularly abundant in arugula. Erucin shows anticancer, neuroprotective, and anti-inflammatory activities.
体内研究：
Erucin (ERU) (0-300 nM) significantly inhibits TPA-induced edema formation.Erucin (30 μmol/kg; i.p.; twice a week for 4 week) shows neuroprotective effects.Animal Model:Female ICR mice (4 weeks of age), TPA (12-O-tetradecanoylphorbol-13-acetate)-induced mouse ear edema model
Dosage:0, 100, and 300 nM
Administration:Topically applied to the mouse ear 30 min prior to the topical application of TPA
Result:Significantly inhibited TPA-induced edema formation.
Animal Model:Male C57Bl/6 mice (9 weeks old, 25–30 g body weight)
Dosage:30 μmol/kg
Administration:Intraperitoneal administration, twice a week, 4 weeks (Induce brain lesion by intrastriatal injection of 6-OHDA)
Result:Induced a partial recovery in the rotational behavior test. Upregulated the expression of TH. Counteract neuronal death and DNA fragmentation in 6-OHDA lesioned mice. increase total GSH and Nrf2 levels in 6-OHDA lesioned mice.
体外研究：
Erucin (ERU) (0-100 μM) releases H2S and inhibits cell viability in AsPC‐1 cells in a concentration-dependent manner.Erucin inhibits cell migration and altered the AsPC‐1 cell cycle, reducing G0/G1 phase and increasing G2/M and S phases.Erucin (30 μM, 72 h) induces AsPC‐1 cell apoptosis and inhibits cell migration.Erucin reduces levels of phosphorylated ERK1/2 in AsPC‐1 cells.Erucin (0-200 μM, 24 h) shows antiproliferative activity with an IC50 of 97.7 μM in A549 cells. Erucin (0-50 μM, 24 h) induces the cleavage of PARP-1 at 50 μM, and increases p53 and p21 protein expression in A549 cells.Erucin decreases LPS-induced production of NO, prostaglandin E2 (PGE2), TNF-α, IL-6 and IL-1β in RAW 264.7 cells.Erucin decreases LPS-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in RAW 264.7 cells.Erucin inhibits LPS-induced activation of NFκB Signaling in RAW 264.7 cells.
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