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编 号:F362048
分子式:C13H19NO3S
分子量:269.36
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
AA92593 is a selective and competitive OPN4 (melanopsin) antagonist.

体内研究:
AA92593 is able to decrease IOP in rabbits living under normal light condition.AA92593 produces an increment in melatonin levels resulting in a drop of IOP.Animal Model:Wild type (WT) mice.
Dosage:30 mg/kg.
Administration:IP 20 min prior to PLR measurement.
Result:Attenuated pupil constriction in response to light (1013 ph.cm?2.s?1) by ~50%.

体外研究:
AA92593 is a competitive melanopsin antagonist, its presence in the retinal-binding pocket of melanopsin leads to the displacement of retinal, which could trigger a downstream signaling that would ultimately result in Per1 increased expression.AA92593 is shown to be specific because it competes with retinaldehyde for the melanopsin retinal binding site which is very distinct from other opsins.Inhibition of melanopsin activity with AA92593 increases a-MSH expression and induces melanin dispersion in the melanophores, which darkens the embryo.AA92593 exhibits an IC50 of 665 nM in CHOOpn4 cells.
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