产品
编 号：F363542
分子式：C27H39NO3
分子量：425.6
分子式：C27H39NO3
分子量：425.6
产品类型
规格
价格
是否有货
5mg
648
In-stock
10mg
1200
In-stock
50mg
5480
In-stock
结构图
CAS No: 469-59-0
产品详情
生物活性：
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties.
体内研究：
Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.Animal Model:Male Sprague Dawley rats (180-200? g)
Dosage:50, 100, 200 and 400? mg/kg
Administration:Orally
Result:Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.
体外研究：
Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation. Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis.
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties.
体内研究：
Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.Animal Model:Male Sprague Dawley rats (180-200? g)
Dosage:50, 100, 200 and 400? mg/kg
Administration:Orally
Result:Exerted 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema.
体外研究：
Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation. Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备