产品
编 号：F041464
分子式：C16H22ClN3O2
分子量：323.82
分子式：C16H22ClN3O2
分子量：323.82
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 112727-80-7
产品详情
生物活性：
Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study.
体内研究：
Renzapride (BRL 24924) (100 μg i.v.) results in a partial reverse of both the delayed solid and liquid meals emptying.Renzapride (BRL 24924) (0.5-1 mg/kg) significantly increases the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach.Animal Model:Dog (simulating gastroparesis)
Dosage:100 μg/kg
Administration:i.v.
Result:Results in a partial reverse of both the delayed solid and liquid meals emptying.
Animal Model:Mice (30-45g)
Dosage:0.5-1 mg/kg
Administration:p.o.
Result:Significantly increase the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach.
体外研究：
Renzapride replaces specific binding of [H3] GR 113808 (a selective 5-HT receptor antagonist) to cloned human 5-HT4 receptors with a Ki value of 115 nM.
Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study.
体内研究：
Renzapride (BRL 24924) (100 μg i.v.) results in a partial reverse of both the delayed solid and liquid meals emptying.Renzapride (BRL 24924) (0.5-1 mg/kg) significantly increases the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach.Animal Model:Dog (simulating gastroparesis)
Dosage:100 μg/kg
Administration:i.v.
Result:Results in a partial reverse of both the delayed solid and liquid meals emptying.
Animal Model:Mice (30-45g)
Dosage:0.5-1 mg/kg
Administration:p.o.
Result:Significantly increase the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach.
体外研究：
Renzapride replaces specific binding of [H3] GR 113808 (a selective 5-HT receptor antagonist) to cloned human 5-HT4 receptors with a Ki value of 115 nM.
产品资料
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