产品
编 号：F378996
分子式：C15H10FNO3
分子量：271.24
分子式：C15H10FNO3
分子量：271.24
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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结构图
CAS No: 524684-52-4
产品详情
生物活性：
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis.
体内研究：
Prinaberel (2mg/mouse; topically; 30 min prior to UVB irradiation for 30 weeks) suppresses development of squamous cell carcinoma in SKH-1 hairless mice.Prinaberel reduces proliferation and angiogenesis and induces apoptosis in UVB-induced skin tumors. Prinaberel suppresses pro-inflammatory signaling pathway in UVB-induced skin tumors. Prinaberel diminished tumor invasiveness via PI3K-AKT pathway and WNT signaling.Animal Model:Six- to eight-weeks-old SKH-1 hairless female mice
Dosage:2 mg/mouse in 200μl ethanol
Administration:Topically; 30 min prior to UVB (180mJ/cm2) irradiation for 30 weeks
Result:Diminished UVB-induced skin tumor development in SKH-1 hairless mice.
体外研究：
Prinaberel (ERB-041) (0-60 μM; 24 hours) treatment of human SCC cells induces cell differentiation, cell cycle arrest and reduces colony formation.Prinaberel shows a marked reduction in the expression of inflammation regulatory proteins such as p-NFκBp65, iNOS and COX-2 in A431 cells. Prinaberel diminishes phosphorylated-PI3K and -AKT, which is associated with the enhancement in E-cadherin expression and reduction in migration of A431 cells.Prinaberel (0.01-10 μM) inhibits cell proliferation in a dose- and time-dependent manner.Prinaberel (10 μM; 48 hours) promotes ovarian cancer (SKOV-3 cells) apoptosis.
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis.
体内研究：
Prinaberel (2mg/mouse; topically; 30 min prior to UVB irradiation for 30 weeks) suppresses development of squamous cell carcinoma in SKH-1 hairless mice.Prinaberel reduces proliferation and angiogenesis and induces apoptosis in UVB-induced skin tumors. Prinaberel suppresses pro-inflammatory signaling pathway in UVB-induced skin tumors. Prinaberel diminished tumor invasiveness via PI3K-AKT pathway and WNT signaling.Animal Model:Six- to eight-weeks-old SKH-1 hairless female mice
Dosage:2 mg/mouse in 200μl ethanol
Administration:Topically; 30 min prior to UVB (180mJ/cm2) irradiation for 30 weeks
Result:Diminished UVB-induced skin tumor development in SKH-1 hairless mice.
体外研究：
Prinaberel (ERB-041) (0-60 μM; 24 hours) treatment of human SCC cells induces cell differentiation, cell cycle arrest and reduces colony formation.Prinaberel shows a marked reduction in the expression of inflammation regulatory proteins such as p-NFκBp65, iNOS and COX-2 in A431 cells. Prinaberel diminishes phosphorylated-PI3K and -AKT, which is associated with the enhancement in E-cadherin expression and reduction in migration of A431 cells.Prinaberel (0.01-10 μM) inhibits cell proliferation in a dose- and time-dependent manner.Prinaberel (10 μM; 48 hours) promotes ovarian cancer (SKOV-3 cells) apoptosis.
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