产品
编 号：F379299
分子式：C15H13NO3
分子量：255.27
分子式：C15H13NO3
分子量：255.27
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
280
In-stock
100mg
480
In-stock
结构图
CAS No: 52549-17-4
产品详情
生物活性：
Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases.?Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis.
体内研究：
Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.Animal Model:DSS-induced acute colitis in C57BL/6 mice
Dosage:4 mg/kg;16 mg/kg
Administration:Oral administration; 4 mg/kg/16 mg/kg; 9 days
Result:Alleviated inflammation in DSS-induced acute colitis.
体外研究：
Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM)-induced Dicer expression in FHC cells.
Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases.?Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis.
体内研究：
Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice.Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.Animal Model:DSS-induced acute colitis in C57BL/6 mice
Dosage:4 mg/kg;16 mg/kg
Administration:Oral administration; 4 mg/kg/16 mg/kg; 9 days
Result:Alleviated inflammation in DSS-induced acute colitis.
体外研究：
Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells.Pranoprofen (5-25 μM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 μM enhances H2O2 (800 μM)-induced Dicer expression in FHC cells.
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