产品
编 号：F383846
分子式：C42H65NO16
分子量：839.96
分子式：C42H65NO16
分子量：839.96
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
400
In-stock
100mg
560
In-stock
500mg
1680
In-stock
结构图
CAS No: 53956-04-0
产品详情
生物活性：
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
体内研究：
The increase of the lung W/D weight ratios is significantly reduced by high and medium dose of MAG (10 and 30 mg/kg) administration. Pretreatment with MAG (10 and 30 mg/kg) efficiently reduces the production of TNF-α and IL-1β. MAG (10, 30 mg/kg) significantly decreases NF-κB p65 protein expression, compared with LPS. On the contrary, LPS significantly reduces IκB-α protein expression compared with the control group, whereas MAG (10 and 30 mg/kg) significantly increased I??B-?? expression, compared with the LPS group.Low- and high-dose MAG treatment significantly reduces the AST, ALT, TBIL, and TBA levels at 14 and 21 d time points when compared with that of the RIF and INH group, suggesting the protective effect of MAG on RIF- and INH-induced liver injury. MAG treatment groups elevate the hepatic GSH level at 7, 14, and 21 d time points and markedly reduce the MDA level at 14 and 21 d time points in RIF- and INH-treated rats, suggesting the protective effect of MAG in RIF- and INH induced liver injuries.
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
体内研究：
The increase of the lung W/D weight ratios is significantly reduced by high and medium dose of MAG (10 and 30 mg/kg) administration. Pretreatment with MAG (10 and 30 mg/kg) efficiently reduces the production of TNF-α and IL-1β. MAG (10, 30 mg/kg) significantly decreases NF-κB p65 protein expression, compared with LPS. On the contrary, LPS significantly reduces IκB-α protein expression compared with the control group, whereas MAG (10 and 30 mg/kg) significantly increased I??B-?? expression, compared with the LPS group.Low- and high-dose MAG treatment significantly reduces the AST, ALT, TBIL, and TBA levels at 14 and 21 d time points when compared with that of the RIF and INH group, suggesting the protective effect of MAG on RIF- and INH-induced liver injury. MAG treatment groups elevate the hepatic GSH level at 7, 14, and 21 d time points and markedly reduce the MDA level at 14 and 21 d time points in RIF- and INH-treated rats, suggesting the protective effect of MAG in RIF- and INH induced liver injuries.
产品资料
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