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编 号：F393008
分子式：C25H27ClN2
分子量：390.95
分子式：C25H27ClN2
分子量：390.95
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CAS No: 569-65-3
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生物活性：
Meclizine (Meclozine), an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine is a member of the piperazine class of H1 antagonists. Meclizine is an effective anti-motion sickness agent. Meclizine crosses the blood–brain barrier. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine can be used for the research of polyQ toxicity disorders, such as Huntington's disease.
体内研究：
Meclizine (Meclozine; 10-100 mg/kg; ip) protects mouse against kidney ischemia. Pretreatment with 100 mg/kg of Meclizine, 17 or 24 h prior to ischemia shows kidney protection in mice. Meclizine reduces mitochondrial oxygen consumption by directly inhibiting the Kennedy pathway of phosphatidylethanolamine biosynthesis and up-regulated glycolysis.Animal Model:8-10 wk old male C57BL/6 mice
Dosage:10, 30, 60 or 100 mg/kg
Administration:Administered intraperitoneally
Result:Protected mice from kidney ischemia-reperfusion injury.
体外研究：
Meclizine (Meclozine; 50 μM; 24 hours) significantly increases cell survival in STHdhMeclizine 相关抗体:Cell Viability AssayCell Line:The murine striatal cells expressing wild-type (STHdhQ7/7) or mutant (STHdhQ111/111) huntingtin protein
Concentration:50 μM
Incubation Time:24 hours
Result:Significantly increased cell survival in STHdhQ111/111 cells at 24 h after the removal of serum.
Western Blot AnalysisCell Line:Mutant (STHdhQ111/111) and wild-type (STHdhQ7/7) striatal cells
Concentration:50 μM
Incubation Time:0, 4, 10, 24 hours
Result:Suppressed apoptosis, based on caspase 3 and 7 cleavage.
Meclizine (Meclozine), an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine is a member of the piperazine class of H1 antagonists. Meclizine is an effective anti-motion sickness agent. Meclizine crosses the blood–brain barrier. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine can be used for the research of polyQ toxicity disorders, such as Huntington's disease.
体内研究：
Meclizine (Meclozine; 10-100 mg/kg; ip) protects mouse against kidney ischemia. Pretreatment with 100 mg/kg of Meclizine, 17 or 24 h prior to ischemia shows kidney protection in mice. Meclizine reduces mitochondrial oxygen consumption by directly inhibiting the Kennedy pathway of phosphatidylethanolamine biosynthesis and up-regulated glycolysis.Animal Model:8-10 wk old male C57BL/6 mice
Dosage:10, 30, 60 or 100 mg/kg
Administration:Administered intraperitoneally
Result:Protected mice from kidney ischemia-reperfusion injury.
体外研究：
Meclizine (Meclozine; 50 μM; 24 hours) significantly increases cell survival in STHdhMeclizine 相关抗体:Cell Viability AssayCell Line:The murine striatal cells expressing wild-type (STHdhQ7/7) or mutant (STHdhQ111/111) huntingtin protein
Concentration:50 μM
Incubation Time:24 hours
Result:Significantly increased cell survival in STHdhQ111/111 cells at 24 h after the removal of serum.
Western Blot AnalysisCell Line:Mutant (STHdhQ111/111) and wild-type (STHdhQ7/7) striatal cells
Concentration:50 μM
Incubation Time:0, 4, 10, 24 hours
Result:Suppressed apoptosis, based on caspase 3 and 7 cleavage.
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