产品
编 号：F393052
分子式：C28H38O5
分子量：454.6
分子式：C28H38O5
分子量：454.6
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 56973-41-2
产品详情
生物活性：
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.
体内研究：
Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model.Animal Model:Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect
Dosage:10 mg/kg
Administration:Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days)
Result:Increased the trabecular number, trabecular thickness and the thickness of the cortical bone.
体外研究：
Withanolide B (1-100 nM; 3-5 days) significantly increases the expression of COL1A1 and RUNX2 genes and proteins in hBMSCs.Withanolide B (1-100 nM; 11 or 3 days) increases the formation of extracellular matrix calcium deposits and increased the activity of alkaline phosphatase (ALP).Withanolide B (1-100 nM; 3-5 days) increases the protein expressions of p-ERK and active β-catenin of hBMSCs.Withanolide B (10-100 μM; 48 h) reverses the Aβ42 aggregation-induced toxicy in SK-N-SH cells.
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects.
体内研究：
Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model.Animal Model:Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect
Dosage:10 mg/kg
Administration:Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days)
Result:Increased the trabecular number, trabecular thickness and the thickness of the cortical bone.
体外研究：
Withanolide B (1-100 nM; 3-5 days) significantly increases the expression of COL1A1 and RUNX2 genes and proteins in hBMSCs.Withanolide B (1-100 nM; 11 or 3 days) increases the formation of extracellular matrix calcium deposits and increased the activity of alkaline phosphatase (ALP).Withanolide B (1-100 nM; 3-5 days) increases the protein expressions of p-ERK and active β-catenin of hBMSCs.Withanolide B (10-100 μM; 48 h) reverses the Aβ42 aggregation-induced toxicy in SK-N-SH cells.
产品资料
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