产品
编 号：F393501
分子式：C21H19ClFNO4S
分子量：435.9
分子式：C21H19ClFNO4S
分子量：435.9
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 571170-77-9
产品详情
生物活性：
Laropiprant is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.
体内研究：
Laropiprant (0-100 mg/kg; p.o. and i.v.; male Sprague-Dawley rats) exhibits good pharmacokinetic profiles.Pharmacokinetic Analysis in Male Sprague-Dawley ratsRouteDose (mg/kg)AUC0-∞ (μM·hr)Clp (mL/min/kg)Vdss (L/kg)T1/2 (hr)
PO122.71.90.77.4
PO596.02.10.97.6
RouteDose (mg/kg)AUC0-∞ (μM·hr)Cmax (μM)Tmax (hr)F(%)
IV552.615.61.2/
体外研究：
Laropiprant (0.01-1000 μM; 10 mins; HEK293 cells) is an inverse agonist of DP1 cAMP signaling and reduces DP1 cAMP signaling below basal levels.Laropiprant (1 μM; 0-24 h; HEK293 cells) is a pharmacochaperone in promoting DP1 cell surface expression.
Laropiprant is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.
体内研究：
Laropiprant (0-100 mg/kg; p.o. and i.v.; male Sprague-Dawley rats) exhibits good pharmacokinetic profiles.Pharmacokinetic Analysis in Male Sprague-Dawley ratsRouteDose (mg/kg)AUC0-∞ (μM·hr)Clp (mL/min/kg)Vdss (L/kg)T1/2 (hr)
PO122.71.90.77.4
PO596.02.10.97.6
RouteDose (mg/kg)AUC0-∞ (μM·hr)Cmax (μM)Tmax (hr)F(%)
IV552.615.61.2/
体外研究：
Laropiprant (0.01-1000 μM; 10 mins; HEK293 cells) is an inverse agonist of DP1 cAMP signaling and reduces DP1 cAMP signaling below basal levels.Laropiprant (1 μM; 0-24 h; HEK293 cells) is a pharmacochaperone in promoting DP1 cell surface expression.
产品资料
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