产品
编 号：F394554
分子式：C15H21N3O2
分子量：275.35
分子式：C15H21N3O2
分子量：275.35
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是否有货
1mg
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CAS No: 57-47-6
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生物活性：
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.
体内研究：
Physostigmine (Eserine; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.Physostigmine (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.Animal Model:Heterozygous transgenic mice (Tg(+) mice)
Dosage:0.03, 0.1, and 0.3 mg/kg
Administration:SC; daily for 6 weeks
Result:Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.
体内研究：
Physostigmine (Eserine; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.Physostigmine (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.Animal Model:Heterozygous transgenic mice (Tg(+) mice)
Dosage:0.03, 0.1, and 0.3 mg/kg
Administration:SC; daily for 6 weeks
Result:Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
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