产品
编 号:F395083
分子式:C12H14N4O2S
分子量:278.33
产品类型
结构图
CAS No: 57-68-1
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产品详情
生物活性:
Sulfamethazine (Sulfadimidine) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections). In China and the European Commission, the maximum residue level for Sulfamethazine in animal product is set at 100 μg/kg.
体内研究:
Sulfamethazine (80 mg/kg; intravenous injection; healthy female pigs) treatment significantly reduces α, β and AUC0->∞, significantly increases t1/2α, Vd and CIB, and upon a single intramuscular administration of 80 mg/kg of Sulfamethazine the absolute bioavailability in pigs is 1.01.Animal Model:19 healthy female pigs (6-week-old, 4.5-6.2 kg)
Dosage:80 mg/kg
Administration:Intravenous injection (Pharmacokinetic study)
Result:The half-life in distribution phase is 0.23 h and half-lifes in eliminations phase is 9.8 h. α, β and the AUC0->∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased, and the absolute bioavailability in pigs is 1.01.