产品
编 号：F044244
分子式：C9H13ClNO3P
分子量：249.63
分子式：C9H13ClNO3P
分子量：249.63
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 114012-12-3
产品详情
生物活性：
Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact.
体内研究：
Phaclofen (2 mg/kg; i.p) shows that fewer neuropeptide Y-like immunoreactive fibers are detected in the stimulated cuneate nucleus. Phaclofen (2 mg/kg; s.c) antagonizes the effects of 6 mg/kg R(＋) baclofen in dorsal striatum.Phaclofen (100 nmol; intrathecal injection) antagonizes the depressant effect of baclofen. Phaclofen (100 nmol) is devoid of stimulatory or depressant effects on spinal reflexes.Animal Model:Sprague–Dawley rats (180–250 g)
Dosage:2 mg/kg
Administration:I.p．
Result:Fewer neuropeptide Y-like immunoreactive fibers were detected in the stimulated cuneate nucleus.
Animal Model:Male Wistar rats (280–320 g)
Dosage:2 mg/kg
Administration:S.c.
Result:Antagonized the effects of 6 mg/kg R(＋) baclofen in dorsal striatum.
体外研究：
The GABAB antagonist phaclofen (500 μM) partly prevents the effect of 1 μM of (R＋) baclofen.
Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact.
体内研究：
Phaclofen (2 mg/kg; i.p) shows that fewer neuropeptide Y-like immunoreactive fibers are detected in the stimulated cuneate nucleus. Phaclofen (2 mg/kg; s.c) antagonizes the effects of 6 mg/kg R(＋) baclofen in dorsal striatum.Phaclofen (100 nmol; intrathecal injection) antagonizes the depressant effect of baclofen. Phaclofen (100 nmol) is devoid of stimulatory or depressant effects on spinal reflexes.Animal Model:Sprague–Dawley rats (180–250 g)
Dosage:2 mg/kg
Administration:I.p．
Result:Fewer neuropeptide Y-like immunoreactive fibers were detected in the stimulated cuneate nucleus.
Animal Model:Male Wistar rats (280–320 g)
Dosage:2 mg/kg
Administration:S.c.
Result:Antagonized the effects of 6 mg/kg R(＋) baclofen in dorsal striatum.
体外研究：
The GABAB antagonist phaclofen (500 μM) partly prevents the effect of 1 μM of (R＋) baclofen.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备