产品
编 号：F395899
分子式：C22H25N3
分子量：331.45
分子式：C22H25N3
分子量：331.45
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 57961-90-7
产品详情
生物活性：
Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of? haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce?systemic vascular resistance in haemorrhagic models.
体内研究：
Centhaquine (Centhaquin) (intravenous?injection, 0.01-1.0 mg/kg;intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner.Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci.Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of?catecholamines, improving both the macro- and?microcirculation?during CPR.Animal Model:Landrace/Large White piglets
Dosage:0.015mg/kg
Administration:Intravenous administration; Adrenaline 0.02mg/kg plus Centhaquin 0.015mg/kg
Result:Added to adrenaline improved ROSC rates in a swine model of VF cardiac arrest.
Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of? haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce?systemic vascular resistance in haemorrhagic models.
体内研究：
Centhaquine (Centhaquin) (intravenous?injection, 0.01-1.0 mg/kg;intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner.Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci.Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of?catecholamines, improving both the macro- and?microcirculation?during CPR.Animal Model:Landrace/Large White piglets
Dosage:0.015mg/kg
Administration:Intravenous administration; Adrenaline 0.02mg/kg plus Centhaquin 0.015mg/kg
Result:Added to adrenaline improved ROSC rates in a swine model of VF cardiac arrest.
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