产品
编 号：F396600
分子式：C11H6ClF2N3O
分子量：269.63
分子式：C11H6ClF2N3O
分子量：269.63
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 582323-16-8
产品详情
生物活性：
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells.
体外研究：
ICA-069673（100 nM-30 μM）剂量依赖性地抑制豚鼠 DSM 分离试纸中的自发相位收缩、药理学诱导的收缩和 10 Hz EFS 诱导的神经诱发收缩。ICA-069673（3 μM，10 μM）抑制豚鼠 DSM 分离条中 20 mM KCl 诱导的 DSM 强直收缩。
ICA-069673 is a KCNQ2/Q3 potassium channel activator. ICA-069673 demonstrates greater selectivity for KV7.2/7.3 over KV7.3/KV7.5, with EC50s of 0.69 μM and 14.3 μM, respectively. ICA-069673 inhibits spontaneous phasic and nerve-evoked contractions in guinea pig detrusor smooth muscle (DSM). ICA-069673 also decreases the global intracellular Ca(2+) concentration in DSM cells.
体外研究：
ICA-069673（100 nM-30 μM）剂量依赖性地抑制豚鼠 DSM 分离试纸中的自发相位收缩、药理学诱导的收缩和 10 Hz EFS 诱导的神经诱发收缩。ICA-069673（3 μM，10 μM）抑制豚鼠 DSM 分离条中 20 mM KCl 诱导的 DSM 强直收缩。
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