产品
编 号：F396645
分子式：C8H10O3
分子量：154.16
分子式：C8H10O3
分子量：154.16
产品类型
规格
价格
是否有货
结构图
CAS No: 582-46-7
产品详情
生物活性：
Terrein is a melanogenesis inhibitor. Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa.
体外研究：
Treatment of Mel-Ab cells with Terrein (10-100 μM) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation.Terrein (5-500 μM; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners.Terrein (150, 250, 500μM; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75 μM) were used for subsequent experiments.Terrein (25 and 75 μM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75 μM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells.Terrein (75 μM) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75 μM) inhibits the expression of RhoB, p-Rac1 in MDA-MB-231 cells.Terrein (10, 30, and 100?μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains.
Terrein is a melanogenesis inhibitor. Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa.
体外研究：
Treatment of Mel-Ab cells with Terrein (10-100 μM) for 4 days significantly reduces melanin levels in a dose-dependent manner. Terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation.Terrein (5-500 μM; 24 and 48 hours) reduces the viability of these cells in concentration- and time-dependent manners.Terrein (150, 250, 500μM; 24 hours) induces programmed cell death in both invasive and non-invasive breast cancer cell lines. Thus, the optimal non-toxic concentrations of Terrein (25 and 75 μM) were used for subsequent experiments.Terrein (25 and 75 μM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MDA-MB-231 cells. Terrein (75 μM) significantly decrease the mRNA levels of both MMP-2 and MMP-9 in MCF-7 cells.Terrein (75 μM) inhibits the expression of RhoA, RhoB, p-Rac1 in MCF-7 cells. Terrein (75 μM) inhibits the expression of RhoB, p-Rac1 in MDA-MB-231 cells.Terrein (10, 30, and 100?μM) inhibits the production of virulence factors such as elastase, pyocyanin, and rhamnolipid, as well as biofilm formation in P. aeruginosa PAO1 and PA14 strains.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备