产品
编 号：F397346
分子式：C22H25NO8
分子量：431.44
分子式：C22H25NO8
分子量：431.44
产品类型
规格
价格
是否有货
结构图
CAS No: 58523-30-1
产品详情
生物活性：
Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50=3.6 μM). Antitumor activity.
体内研究：
Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity.Animal Model:HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode)
Dosage:10 mg/kg
Administration:P.o.; 7X/week, 30 days
Result:Significantly suppressed the growth of BT474 tumors.
体外研究：
Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC50 value of 1.2 μM. Pseurotin A (25-100 μM; 72 hours) significantly suppressed the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines. Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner.Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells.
Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50=3.6 μM). Antitumor activity.
体内研究：
Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity.Animal Model:HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode)
Dosage:10 mg/kg
Administration:P.o.; 7X/week, 30 days
Result:Significantly suppressed the growth of BT474 tumors.
体外研究：
Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC50 value of 1.2 μM. Pseurotin A (25-100 μM; 72 hours) significantly suppressed the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines. Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner.Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备