产品
编 号：F397427
分子式：C13H12Cl2O4
分子量：303.14
分子式：C13H12Cl2O4
分子量：303.14
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 58-54-8
产品详情
生物活性：
Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma.
体内研究：
Ethacrynic acid (450 μg/mouse; 口服给药; 一天一次连续60天) 能够抑制小鼠中的胞瘤生长。Animal Model:Myeloma Balb/c mice model
Dosage:450 μg/mouse
Administration:Oral gavage (p.o.); Once daily for 60 days. After BALB/c mice were injected subcutaneously with 5 × 105 MPC11 myeloma cells.
Result:Significantly inhibited tumor growth.
体外研究：
Ethacrynic acid (50 μM; 24 小时) 抑制 CLL 细胞中 Wnt/β-catenin 的信号传导。Ethacrynic acid (1-100 μM; 48 小时) 在 CLL 细胞中具有细胞毒性，IC50 为 8.56 μM。Ethacrynic acid (0.01-0.25 mmol/L; 30 分钟) 增加眼睛的房水流出，出水率由28%提高到105%。Ethacrynic acid (10-100 μM; 30 分钟) 在 LPS (100 ng/mL) 诱导的 RAW264.7 细胞中能够抑制 NF-κB 通路的激活，具有抗炎活性。Ethacrynic acid (20 μM/mL; 2 小时) 可以增强经辐射照射后的 MCF-7 癌细胞中的辐射强度。Ethacrynic acid (100 μmol/L; 62.5-250分钟) 以剂量依赖性的方式抑制高 –K+ (80 mmol/L) 和乙酰胆碱 (acetylcholine, ACh, 100 μmol/L) 引起的小鼠气管环收缩，EC50 分别为 40.28 μmol/L 和 56.22 μmol/L。Ethacrynic acid (100 μmol/L; 500-2500 秒) 分别降低高 –K+ 和 ACh 诱导的细胞内 Ca2+ 浓度，分别从 0.40 降到 0.16，0.50 降到 0.39 。
Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma.
体内研究：
Ethacrynic acid (450 μg/mouse; 口服给药; 一天一次连续60天) 能够抑制小鼠中的胞瘤生长。Animal Model:Myeloma Balb/c mice model
Dosage:450 μg/mouse
Administration:Oral gavage (p.o.); Once daily for 60 days. After BALB/c mice were injected subcutaneously with 5 × 105 MPC11 myeloma cells.
Result:Significantly inhibited tumor growth.
体外研究：
Ethacrynic acid (50 μM; 24 小时) 抑制 CLL 细胞中 Wnt/β-catenin 的信号传导。Ethacrynic acid (1-100 μM; 48 小时) 在 CLL 细胞中具有细胞毒性，IC50 为 8.56 μM。Ethacrynic acid (0.01-0.25 mmol/L; 30 分钟) 增加眼睛的房水流出，出水率由28%提高到105%。Ethacrynic acid (10-100 μM; 30 分钟) 在 LPS (100 ng/mL) 诱导的 RAW264.7 细胞中能够抑制 NF-κB 通路的激活，具有抗炎活性。Ethacrynic acid (20 μM/mL; 2 小时) 可以增强经辐射照射后的 MCF-7 癌细胞中的辐射强度。Ethacrynic acid (100 μmol/L; 62.5-250分钟) 以剂量依赖性的方式抑制高 –K+ (80 mmol/L) 和乙酰胆碱 (acetylcholine, ACh, 100 μmol/L) 引起的小鼠气管环收缩，EC50 分别为 40.28 μmol/L 和 56.22 μmol/L。Ethacrynic acid (100 μmol/L; 500-2500 秒) 分别降低高 –K+ 和 ACh 诱导的细胞内 Ca2+ 浓度，分别从 0.40 降到 0.16，0.50 降到 0.39 。
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