产品
编 号：F397531
分子式：C10H8Cl3N3O
分子量：292.55
分子式：C10H8Cl3N3O
分子量：292.55
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 58579-51-4
产品详情
生物活性：
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36?nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action.
体内研究：
Anagrelide hydrochloride (BL4162A; 5 mg/kg/bid；持续 10 天) 抑制或减少 GIST2B、GIST9、GIST882 模型中的肿瘤生长。Animal Model:Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model
Dosage:5 mg/kg
Administration:Twice daily; for 10 days
Result:Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
体外研究：
Anagrelide hydrochloride (BL4162A) 有效抑制骨髓巨核细胞的发育 (IC50=26?nM)。Anagrelide(0.05、0.3、1 μM；12 天) hydrochloride 仅抑制巨核细胞生长，不抑制非巨核细胞生长。Anagrelide (0.1-10000 nM) hydrochloride 在 GIST882 细胞系中诱导细胞毒性作用。
Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36?nM). Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action.
体内研究：
Anagrelide hydrochloride (BL4162A; 5 mg/kg/bid；持续 10 天) 抑制或减少 GIST2B、GIST9、GIST882 模型中的肿瘤生长。Animal Model:Adult female athymic mice bearing GIST2B, GIST3, GIST9, GIST882 model
Dosage:5 mg/kg
Administration:Twice daily; for 10 days
Result:Inhibited or reduced tumor growth in three (GIST2B, GIST9, GIST882) of these four models.
体外研究：
Anagrelide hydrochloride (BL4162A) 有效抑制骨髓巨核细胞的发育 (IC50=26?nM)。Anagrelide(0.05、0.3、1 μM；12 天) hydrochloride 仅抑制巨核细胞生长，不抑制非巨核细胞生长。Anagrelide (0.1-10000 nM) hydrochloride 在 GIST882 细胞系中诱导细胞毒性作用。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备