产品
编 号：F397708
分子式：C10H12N4O5
分子量：268.23
分子式：C10H12N4O5
分子量：268.23
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
280
In-stock
1g
400
In-stock
10g
480
In-stock
25g
560
In-stock
结构图
CAS No: 58-63-9
产品详情
生物活性：
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
体内研究：
Inosine 可用于动物建模，构建高尿酸模型。Animal Model:Male/female C57BL/6 mice
Dosage:1 mg/kg, 10 mg/kg, 100 mg/kg
Administration:Intraperitoneal injection, 20 min before formalin treatment
Result:Reduced flinching behaviour induced by formalin (2 %; 20 μL; intraplantar injection).
体外研究：
Inosine dose-dependently stimulates cAMP production mediated through the A2AR.?Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation.?Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors.
体内研究：
Inosine 可用于动物建模，构建高尿酸模型。Animal Model:Male/female C57BL/6 mice
Dosage:1 mg/kg, 10 mg/kg, 100 mg/kg
Administration:Intraperitoneal injection, 20 min before formalin treatment
Result:Reduced flinching behaviour induced by formalin (2 %; 20 μL; intraplantar injection).
体外研究：
Inosine dose-dependently stimulates cAMP production mediated through the A2AR.?Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation.?Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.
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