产品
编 号：F398268
分子式：C10H16N2O3S
分子量：244.31
分子式：C10H16N2O3S
分子量：244.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
1g
520
In-stock
5g
1520
In-stock
结构图
CAS No: 58-85-5
产品详情
生物活性：
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
体内研究：
Biotin (15 mg/kg/d; p.o.; 12 d) improves nephrotoxicity in streptozotocin-induced (150 mg/kg; i.p.) diabetic mice.Biotin (0.012 mg/kg/d; p.o.; 70 d) deficiency impaires the immune function of the head kidney, spleen and skin in fish with inadequate administration dose.Animal Model:Streptozotocin-induced Diabetes type 1 in male Swiss albino mice (25±2 g)
Dosage:15 mg/kg/d
Administration:Oral gavage; 12 days
Result:Improved histopathological results, including distorted glomeruli, inflammatory cells, and giant macrophages, and diminished acroline reaction of oxidative damage.
Animal Model:Grass carp (117±0.5 g)
Dosage:0.012, 0.110, 0.214, 0.311, 0.427, and 0.518 mg/kg
Administration:Oral gavage; 70 days
Result:Reduced the activities of lysozyme (LZ) and acid phosphatase (ACP), decreased the contents of complement 3 (C3), C4 and immunoglobulin M (IgM).Reduced the mRNA levels of anti-microbial substances.Increased the mRNA levels of pro-inflammatory cytokines, tumour necrosis factor partially and reduced anti-inflammatory IL-4/13A, IL-10, IL-11 and TGF-β1 mRNA levels partially in association with target of rapamycin (TOR) signaling.
体外研究：
Biotin exhibits higher affinity on breast cancer (T47D) cells over normal mammary epithelial (MCF-12A) cells, with Kms of 9.24 μM and 53.1 μM, respecetively.Biotin (0.09-100 μM; 0-70 min) is dose-dependently uptake by T47D cells with Vmax of 27.34 pmol/mg protein/min.Biotin (1-1000 nM; 24 h) exerts function in the recovery of 7β-OHC (50?μM)-induced cell death and reduces cell adhesion.
Biotin, vitamin B7 and serves as a coenzyme for five carboxylases in humans, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. Biotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.
体内研究：
Biotin (15 mg/kg/d; p.o.; 12 d) improves nephrotoxicity in streptozotocin-induced (150 mg/kg; i.p.) diabetic mice.Biotin (0.012 mg/kg/d; p.o.; 70 d) deficiency impaires the immune function of the head kidney, spleen and skin in fish with inadequate administration dose.Animal Model:Streptozotocin-induced Diabetes type 1 in male Swiss albino mice (25±2 g)
Dosage:15 mg/kg/d
Administration:Oral gavage; 12 days
Result:Improved histopathological results, including distorted glomeruli, inflammatory cells, and giant macrophages, and diminished acroline reaction of oxidative damage.
Animal Model:Grass carp (117±0.5 g)
Dosage:0.012, 0.110, 0.214, 0.311, 0.427, and 0.518 mg/kg
Administration:Oral gavage; 70 days
Result:Reduced the activities of lysozyme (LZ) and acid phosphatase (ACP), decreased the contents of complement 3 (C3), C4 and immunoglobulin M (IgM).Reduced the mRNA levels of anti-microbial substances.Increased the mRNA levels of pro-inflammatory cytokines, tumour necrosis factor partially and reduced anti-inflammatory IL-4/13A, IL-10, IL-11 and TGF-β1 mRNA levels partially in association with target of rapamycin (TOR) signaling.
体外研究：
Biotin exhibits higher affinity on breast cancer (T47D) cells over normal mammary epithelial (MCF-12A) cells, with Kms of 9.24 μM and 53.1 μM, respecetively.Biotin (0.09-100 μM; 0-70 min) is dose-dependently uptake by T47D cells with Vmax of 27.34 pmol/mg protein/min.Biotin (1-1000 nM; 24 h) exerts function in the recovery of 7β-OHC (50?μM)-induced cell death and reduces cell adhesion.
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