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编 号：F398730
分子式：C21H28N2O3
分子量：356.46
分子式：C21H28N2O3
分子量：356.46
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CAS No: 5897-19-8
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生物活性：
Cyclizine lactate, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine lactate can be used for the research of nausea, vomiting, and dizziness.
体内研究：
Cyclizine (1-10 mg/kg) lactate enhances locomotor activity of mice in a dose-dependent manner.
体外研究：
Cyclizine (100 μM) lactate significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine lactate inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.
Cyclizine lactate, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine lactate can be used for the research of nausea, vomiting, and dizziness.
体内研究：
Cyclizine (1-10 mg/kg) lactate enhances locomotor activity of mice in a dose-dependent manner.
体外研究：
Cyclizine (100 μM) lactate significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine lactate inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.
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