产品
编 号：F399130
分子式：C34H36O7
分子量：556.65
分子式：C34H36O7
分子量：556.65
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
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10mg
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询价
结构图
CAS No: 59086-90-7
产品详情
生物活性：
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells.
体内研究：
Ingenol 3,20-dibenzoate (20 μg/小鼠；腹腔注射；在第 3、7 和 11 天) 减轻了体内小鼠模型中 5-氟尿嘧啶诱导的贫血。Animal Model:Male C57BL/6 mice (8–12 weeks old)
Dosage:20 μg/mouse
Administration:I.p.; On days 3, 7, and 11
Result:Severity of 5-FU–induced anemia was lessened by IDB treatment on days 12 and 20.
体外研究：
Ingenol 3,20-dibenzoate (0-10000 nM；4 hours) 增强 NK 细胞 (受 A549 细胞和 H1299 细胞刺激) 脱颗粒。 Ingenol 3,20-dibenzoate (0.001-10 μg/mL) 剂量依赖性地促进 UT-7/EPO 细胞增殖，EC50 为 0.27 μg/mL (485 nM)。
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells.
体内研究：
Ingenol 3,20-dibenzoate (20 μg/小鼠；腹腔注射；在第 3、7 和 11 天) 减轻了体内小鼠模型中 5-氟尿嘧啶诱导的贫血。Animal Model:Male C57BL/6 mice (8–12 weeks old)
Dosage:20 μg/mouse
Administration:I.p.; On days 3, 7, and 11
Result:Severity of 5-FU–induced anemia was lessened by IDB treatment on days 12 and 20.
体外研究：
Ingenol 3,20-dibenzoate (0-10000 nM；4 hours) 增强 NK 细胞 (受 A549 细胞和 H1299 细胞刺激) 脱颗粒。 Ingenol 3,20-dibenzoate (0.001-10 μg/mL) 剂量依赖性地促进 UT-7/EPO 细胞增殖，EC50 为 0.27 μg/mL (485 nM)。
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