产品
编 号：F399681
分子式：C8H11N5O3
分子量：225.2
分子式：C8H11N5O3
分子量：225.2
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
440
In-stock
100mg
704
In-stock
500mg
1200
In-stock
结构图
CAS No: 59277-89-3
产品详情
生物活性：
Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia.
体内研究：
Acyclovir (20 mg/kg; p.o.; three times daily; for 10 days; BALB/c mice) treatment in infected mice suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production.Animal Model:Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1
Dosage:20 mg/kg
Administration:Oral administration; three times daily; for 10 days
Result:Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
体外研究：
Acyclovir (Aciclovir, 3-100 μM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent.?Acyclovir (Aciclovir, 10-100 μM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner.?Acyclovir (Aciclovir, 10-100 μM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation.
Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia.
体内研究：
Acyclovir (20 mg/kg; p.o.; three times daily; for 10 days; BALB/c mice) treatment in infected mice suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production.Animal Model:Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1
Dosage:20 mg/kg
Administration:Oral administration; three times daily; for 10 days
Result:Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
体外研究：
Acyclovir (Aciclovir, 3-100 μM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent.?Acyclovir (Aciclovir, 10-100 μM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner.?Acyclovir (Aciclovir, 10-100 μM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation.
产品资料
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