产品
编 号：F399806
分子式：C37H71NO15
分子量：769.96
分子式：C37H71NO15
分子量：769.96
产品类型
规格
价格
是否有货
结构图
CAS No: 59319-72-1
产品详情
生物活性：
Erythromycin A dihydrate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin A dihydrate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin A dihydrate also exhibits antitumor and neuroprotective effect in different fields of research.
体内研究：
Erythromycin A dihydrate (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice.Erythromycin A dihydrate (gastric intubation; 5 mg/kg) protects mice alive even at 120 days after inoculation, but shortens mean survival time in tumor-bearing mice by 4-5 days with dose of 50 mg/kg.Erythromycin A dihydrate (i.h.; single injection; 50 mg/kg) has a protective effect on the rat model with cerebral ischemia reperfusion-injury.Animal Model:Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 cells
Dosage:0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
Administration:Gastric intubation; 30-120 days
Result:Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortened the MST in tumorbearing mice.
Animal Model:Male Sprague-Dawley rats (8-week-old, 250-300 g)
Dosage:50 mg/kg
Administration:Subcutaneous single injection
Result:Reduced infarct volume and edema volume, improved neurological deficit.
体外研究：
Erythromycin A dihydrate inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively.Erythromycin A dihydrate (10 μM, 100 μM; 24 h, 72 h) shows antioxidant and anti-inflammatory effects and suppresses the accumulation of 4-HNE (pErythromycin A dihydrate 相关抗体:Cell Viability AssayCell Line:Embryos primary cortical neuron (from the cerebral cortices of 17-day-old Sprague-Dawley rat)
Concentration:10, 100 μM
Incubation Time:24, 72 hours
Result:Improved the viability of cultured neuronal cells in vitro after 3 hours oxygen-glucose deprivation (OGD).
Erythromycin A dihydrate is a macrolide antibiotic produced by actinomycete?Streptomyces erythreus?with a broad spectrum of antimicrobial activity. Erythromycin A dihydrate binds to bacterial 50S ribosomal subunits and inhibits?RNA-dependent protein synthesis?by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid. Erythromycin A dihydrate also exhibits antitumor and neuroprotective effect in different fields of research.
体内研究：
Erythromycin A dihydrate (gastric intubation; 0.1-50 mg/kg; 30-120 days) decreases tumor growth and prolong the survival time of mice from dose of 5 mg/kg in mice.Erythromycin A dihydrate (gastric intubation; 5 mg/kg) protects mice alive even at 120 days after inoculation, but shortens mean survival time in tumor-bearing mice by 4-5 days with dose of 50 mg/kg.Erythromycin A dihydrate (i.h.; single injection; 50 mg/kg) has a protective effect on the rat model with cerebral ischemia reperfusion-injury.Animal Model:Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 cells
Dosage:0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
Administration:Gastric intubation; 30-120 days
Result:Decreased tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortened the MST in tumorbearing mice.
Animal Model:Male Sprague-Dawley rats (8-week-old, 250-300 g)
Dosage:50 mg/kg
Administration:Subcutaneous single injection
Result:Reduced infarct volume and edema volume, improved neurological deficit.
体外研究：
Erythromycin A dihydrate inhibits growth of P. falciparum with IC50 and IC90 values of 58.2 μM and 104.0 μM, respectively.Erythromycin A dihydrate (10 μM, 100 μM; 24 h, 72 h) shows antioxidant and anti-inflammatory effects and suppresses the accumulation of 4-HNE (pErythromycin A dihydrate 相关抗体:Cell Viability AssayCell Line:Embryos primary cortical neuron (from the cerebral cortices of 17-day-old Sprague-Dawley rat)
Concentration:10, 100 μM
Incubation Time:24, 72 hours
Result:Improved the viability of cultured neuronal cells in vitro after 3 hours oxygen-glucose deprivation (OGD).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备