产品
编 号：F401793
分子式：C4H8O3
分子量：104.1
分子式：C4H8O3
分子量：104.1
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
560
In-stock
结构图
CAS No: 600-15-7
产品详情
生物活性：
2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite. 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia. 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury.
体内研究：
2-Hydroxybutyric acid (250 mg/kg/天，腹腔注射，三天) 预防 C57 小鼠体内 AP 诱导的肝损伤，调节参与炎症反应、氧化应激、细胞增殖和 DNA 损伤的基因表达，使其正常化。Animal Model:AP-induced liver injury in C57 mice
Dosage:250 mg/kg/day
Administration:i.p. for 3 days
Result:Prevented AP-induced liver injury.
体外研究：
2-Hydroxybutyric acid 胰岛素抵抗的副产物，会导致胰岛素信号传导受损和线粒体超载。2-Hydroxybutyric acid (0-40 mM) 可增强 BRL3A、AML12 和小鼠原代肝细胞的细胞活力并降低 AP 诱导的细胞毒性。
2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite. 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia. 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury.
体内研究：
2-Hydroxybutyric acid (250 mg/kg/天，腹腔注射，三天) 预防 C57 小鼠体内 AP 诱导的肝损伤，调节参与炎症反应、氧化应激、细胞增殖和 DNA 损伤的基因表达，使其正常化。Animal Model:AP-induced liver injury in C57 mice
Dosage:250 mg/kg/day
Administration:i.p. for 3 days
Result:Prevented AP-induced liver injury.
体外研究：
2-Hydroxybutyric acid 胰岛素抵抗的副产物，会导致胰岛素信号传导受损和线粒体超载。2-Hydroxybutyric acid (0-40 mM) 可增强 BRL3A、AML12 和小鼠原代肝细胞的细胞活力并降低 AP 诱导的细胞毒性。
产品资料
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