产品
编 号：F402775
分子式：C20H31CaN7O12
分子量：601.58
分子式：C20H31CaN7O12
分子量：601.58
产品类型
规格
价格
是否有货
100mg
440
In-stock
500mg
1440
In-stock
结构图
CAS No: 6035-45-6
产品详情
生物活性：
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.
体内研究：
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).Animal Model:24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)
Dosage:7.0 mg/kg
Administration:Intraperitoneal injection; every second day; for 3 weeks
Result:Following methotrexate (MTX) administration appears to reverse this growth inhibition.
体外研究：
MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .
Folinic acid calcium salt pentahydrate (Leucovorin calcium salt pentahydrate) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.
体内研究：
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).Animal Model:24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)
Dosage:7.0 mg/kg
Administration:Intraperitoneal injection; every second day; for 3 weeks
Result:Following methotrexate (MTX) administration appears to reverse this growth inhibition.
体外研究：
MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) .
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备