产品
编 号：F403282
分子式：C7H17Cl2N2O3P
分子量：279.1
分子式：C7H17Cl2N2O3P
分子量：279.1
产品类型
规格
价格
是否有货
100mg
576
In-stock
500mg
920
In-stock
1g
1288
In-stock
结构图
CAS No: 6055-19-2
产品详情
生物活性：
Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
体内研究：
Cyclophosphamide (injected i.p.;2mg/mouse in 0.1 mL PBS, in C3H mice bearing SW1 tumors) increases the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.Animal Model:Six to eight-week old female C3H/HeN mice bearing SW1 tumors
Dosage:2 mg/mouse
Administration:Injected i.p.; 2mg/mouse in 0.1 mL PBS; Four days
Result:Increased the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.
体外研究：
Cyclophosphamide induces outer membrane blebbing, leads to DNA fragmentation, as revealed by TUNEL staining of free 3'-OH DNA ends, and induces cleavage of the caspase 3 and caspase 7 substrate PARP in 9L/P450 cells. Bcl-2 expression fully blocks the activation of both initiator caspases as well as the effector caspase 3 in cells treated with activated Cyclophosphamide. Bcl-2 inhibits the cytotoxic effects but not the cytostatic effects of activated Cyclophosphamide.Cyclophosphamide inhibits the AChE reversibly with an IC50 of 511 μM.Carbon tetrachloride does not affect the direct cytotoxicity of cyclophosphamide or 4-hydroxycyclophosphamide to cells in culture.
Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
体内研究：
Cyclophosphamide (injected i.p.;2mg/mouse in 0.1 mL PBS, in C3H mice bearing SW1 tumors) increases the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.Animal Model:Six to eight-week old female C3H/HeN mice bearing SW1 tumors
Dosage:2 mg/mouse
Administration:Injected i.p.; 2mg/mouse in 0.1 mL PBS; Four days
Result:Increased the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.
体外研究：
Cyclophosphamide induces outer membrane blebbing, leads to DNA fragmentation, as revealed by TUNEL staining of free 3'-OH DNA ends, and induces cleavage of the caspase 3 and caspase 7 substrate PARP in 9L/P450 cells. Bcl-2 expression fully blocks the activation of both initiator caspases as well as the effector caspase 3 in cells treated with activated Cyclophosphamide. Bcl-2 inhibits the cytotoxic effects but not the cytostatic effects of activated Cyclophosphamide.Cyclophosphamide inhibits the AChE reversibly with an IC50 of 511 μM.Carbon tetrachloride does not affect the direct cytotoxicity of cyclophosphamide or 4-hydroxycyclophosphamide to cells in culture.
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