产品
编 号：F045393
分子式：C20H27N5O6
分子量：433.46
分子式：C20H27N5O6
分子量：433.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
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询价
结构图
CAS No: 114606-56-3
产品详情
生物活性：
SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats.
体内研究：
MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs.MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs.MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs.MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats.Animal Model:Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum
Dosage:3, 10 mg/kg
Administration:I.v. 5 min before antigen challenge
Result:Inhibited antigen-induced bron choconstriction in a dose-related manner.
体外研究：
MKS 492 relaxes airway smooth muscle in vitro.
SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats.
体内研究：
MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs.MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs.MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs.MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats.Animal Model:Female Hartley guinea pigs (250-300 g) were passively sensitized with anti-BPO BGG guinea pig serum
Dosage:3, 10 mg/kg
Administration:I.v. 5 min before antigen challenge
Result:Inhibited antigen-induced bron choconstriction in a dose-related manner.
体外研究：
MKS 492 relaxes airway smooth muscle in vitro.
产品资料
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