产品
编 号：F405140
分子式：C20H29ClN2O4
分子量：396.91
分子式：C20H29ClN2O4
分子量：396.91
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5g
200
In-stock
10g
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询价
结构图
CAS No: 6119-47-7
产品详情
生物活性：
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
体内研究：
Quinine hydrochloride dihydrate (口服灌胃，12或15mg/kg，每周一次，共16周) 对瑞士白化小鼠皮肤癌有一定抑瘤作用。Quinine hydrochloride dihydrate (口服灌胃，10 mg/kg，每天，8周) 导致雄性成年白化大鼠睾丸组织的抗氧化防御系统 SOD、CAT 和 GSH 酶活性降低。Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g)
Dosage:Swiss albino mice 7-8-weeks (weighing 24 g)
Administration:Oral gavage; every week; 16 weeks
Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
体外研究：
Quinine hydrochloride dihydrate (150 μM，30 min) 抑制 DENV (登革热病毒) 在人肝癌 HepG2 细胞系中的增殖。 Quinine hydrochloride dihydrate (37.5-150 μM，24 小时) 在人肝癌 HepG2 细胞系中以剂量依赖性方式显著降低病毒 DENV RNA 和蛋白质水平。
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
体内研究：
Quinine hydrochloride dihydrate (口服灌胃，12或15mg/kg，每周一次，共16周) 对瑞士白化小鼠皮肤癌有一定抑瘤作用。Quinine hydrochloride dihydrate (口服灌胃，10 mg/kg，每天，8周) 导致雄性成年白化大鼠睾丸组织的抗氧化防御系统 SOD、CAT 和 GSH 酶活性降低。Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g)
Dosage:Swiss albino mice 7-8-weeks (weighing 24 g)
Administration:Oral gavage; every week; 16 weeks
Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
体外研究：
Quinine hydrochloride dihydrate (150 μM，30 min) 抑制 DENV (登革热病毒) 在人肝癌 HepG2 细胞系中的增殖。 Quinine hydrochloride dihydrate (37.5-150 μM，24 小时) 在人肝癌 HepG2 细胞系中以剂量依赖性方式显著降低病毒 DENV RNA 和蛋白质水平。
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