产品
编 号：F405145
分子式：C20H30N2O8S
分子量：818.98
分子式：C20H30N2O8S
分子量：818.98
产品类型
规格
价格
是否有货
25g
询价
询价
50g
询价
询价
结构图
CAS No: 6119-70-6
产品详情
生物活性：
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
体内研究：
Quinine sulfate hydrate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice.Quinine sulfate hydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats.Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g)
Dosage:12 mg/kg, 15 mg/kg
Administration:Oral gavage; every week; 16 weeks
Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
体外研究：
Quinine sulfate hydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line.Quinine sulfate hydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line.
Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
体内研究：
Quinine sulfate hydrate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice.Quinine sulfate hydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats.Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g)
Dosage:12 mg/kg, 15 mg/kg
Administration:Oral gavage; every week; 16 weeks
Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
体外研究：
Quinine sulfate hydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line.Quinine sulfate hydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line.
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