产品
编 号：F407724
分子式：C32H46O8
分子量：558.7
分子式：C32H46O8
分子量：558.7
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 6199-67-3
产品详情
生物活性：
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity.
体内研究：
Cucurbitacin B (5 mg/kg, 口服, 10 天) 对大鼠卡拉胶诱导的前列腺炎有保护作用。Cucurbitacin B (20-50 mg/kg, 腹腔注射, 28 天) 可减轻 AD 大鼠的 AD 样症状，保护神经元免受 STZ-ICV 毒性，改善记忆功能。Animal Model:Carrageenan-induced prostatic inflammation in rats
Dosage:5mg/kg/day for 10day
Administration:Oral administration
Result:Decreased the level of TNF-α, IL-1b, COX-2 and iNOS in prostatic tissues.
Animal Model:STZ-ICV rat prototype of AD-like dementia
Dosage:20, 50mg/kg/day for 28days
Administration:Intraperitoneal injection (i.p.)
Result:Decreased the TNF-α, IL-1β, MPO, iNOS, acetylcholinesterase, and glutamate levels, but increased gamma-aminobutyric acid. Increase in viable neuron density in the cortex and hippocampus of rats.
体外研究：
Cucurbitacin B (浓度高达 40 μM, 12-48 h) 在 CCA 细胞系中抑制细胞生长，并使细胞周期进程阻滞在 G2/M 期。葫芦素B (0.1、0.3 和 1 μM) 使 BY4741 酵母细胞中总超氧化物歧化酶(T-SOD) 和 SOD-1 水平升高，而活性氧 (ROS)和丙二醛 (MDA) 水平降低。
Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and is oral active. Cucurbitacin B inhibits tumor cell growth, migration and invasion and cycle arrest, but induces cell apoptosis. Cucurbitacin B has potent anti-inflammatory, antioxidant, antiviral, hypoglycemic, hepatoprotective, neuroprotective activity.
体内研究：
Cucurbitacin B (5 mg/kg, 口服, 10 天) 对大鼠卡拉胶诱导的前列腺炎有保护作用。Cucurbitacin B (20-50 mg/kg, 腹腔注射, 28 天) 可减轻 AD 大鼠的 AD 样症状，保护神经元免受 STZ-ICV 毒性，改善记忆功能。Animal Model:Carrageenan-induced prostatic inflammation in rats
Dosage:5mg/kg/day for 10day
Administration:Oral administration
Result:Decreased the level of TNF-α, IL-1b, COX-2 and iNOS in prostatic tissues.
Animal Model:STZ-ICV rat prototype of AD-like dementia
Dosage:20, 50mg/kg/day for 28days
Administration:Intraperitoneal injection (i.p.)
Result:Decreased the TNF-α, IL-1β, MPO, iNOS, acetylcholinesterase, and glutamate levels, but increased gamma-aminobutyric acid. Increase in viable neuron density in the cortex and hippocampus of rats.
体外研究：
Cucurbitacin B (浓度高达 40 μM, 12-48 h) 在 CCA 细胞系中抑制细胞生长，并使细胞周期进程阻滞在 G2/M 期。葫芦素B (0.1、0.3 和 1 μM) 使 BY4741 酵母细胞中总超氧化物歧化酶(T-SOD) 和 SOD-1 水平升高，而活性氧 (ROS)和丙二醛 (MDA) 水平降低。
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