产品
编 号:F407778
分子式:C42H78N2O14
分子量:835.07
产品类型
结构图
CAS No: 62013-04-1
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产品详情
生物活性:
Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis.
体内研究:
Dirithromycin (s.c. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 1.0, 0.6, and <0.6 mg/kg.Dirithromycin (p.o. for 2 times) is effective against experimental infections caused by S. aureus, S. pyogenes, and S. pneumoniae in mice, with ED50s of 27, 34, and 23 mg/kg.
体外研究:
Dirithromycin possesses an in vitro spectrum of antimicrobial activity which is similar to that of Erythromycin.Dirithromycin exhibits excellent in vitro activity against several strains of Legionella, with MICs of ~1.0 and Dirithromycin 相关抗体: