产品
编 号：F409207
分子式：C6H14O
分子量：102.17
分子式：C6H14O
分子量：102.17
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
168
In-stock
500mg
336
In-stock
结构图
CAS No: 624-95-3
产品详情
生物活性：
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD).
体内研究：
3,3-Dimethyl-1-butanol (1% DMB 溶于水；口服；6 周) 显著降低心力衰竭 (HF) 小鼠的心肌肥大和纤维化。3,3-Dimethyl-1-butanol (0.2% 和 1.0% DMB 溶于水；口服；21 天) 在 ICR mice 中以剂量依赖性方式增加了血清中 TMAO 水平。3,3-Dimethyl-1-butanol 证明了肠道与大脑的相互作用对社会行为具有调节作用。3,3-Dimethyl-1-butanol (1.0% DMB 溶于水；口服；妊娠期与哺乳期) 在怀孕的 Sprague-Dawley 大鼠中，预防 2,3,7,8-四氯双苯环对二??英 (TCDD) 诱导后代高血压。Animal Model:C57BL6/J male mice (8-10 weeks old) with heart failure.
Dosage:1% DMB soluble in water.
Administration:Oral gavage; 6 weeks.
Result:Reduced the plasma trimethylamine N-oxide (TMAO) levels, the cross-sectional area of LV cardiomyocytes, and the area of LV interstitial fibrosis.Decreased the expression of ANP, BNP, β-MHC, collagen Iα, collagen III and CTGF. Inhibited TNF-α, IL-6, IL-1β, p65, TGF-β and Smad3 expression.
Animal Model:Male and female ICR mice (8-weeks old).
Dosage:0.2% and 1.0% DMB soluble in water.
Administration:Oral gavage; 21 d.
Result:Showed insignificantly effect on body weight, water intake, food intake, sexual preference, anxiety, depression and memory formation. Weakened the social dominance of mice.
Animal Model:Pregnant Sprague-Dawley rats.
Dosage:1.0% DMB soluble in water.
Administration:Oral gavage; gestation period and suckling period.
Result:Increased kidney weight, plasma trimethylamine (TMA) level and acetic acid, reduced diastolic. Had significantly effect on gut microbiota composition.
体外研究：
3,3-Dimethyl-1-butanol 是月桂基二甲基磺基甜菜碱/水体系的助表面活性剂。
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD).
体内研究：
3,3-Dimethyl-1-butanol (1% DMB 溶于水；口服；6 周) 显著降低心力衰竭 (HF) 小鼠的心肌肥大和纤维化。3,3-Dimethyl-1-butanol (0.2% 和 1.0% DMB 溶于水；口服；21 天) 在 ICR mice 中以剂量依赖性方式增加了血清中 TMAO 水平。3,3-Dimethyl-1-butanol 证明了肠道与大脑的相互作用对社会行为具有调节作用。3,3-Dimethyl-1-butanol (1.0% DMB 溶于水；口服；妊娠期与哺乳期) 在怀孕的 Sprague-Dawley 大鼠中，预防 2,3,7,8-四氯双苯环对二??英 (TCDD) 诱导后代高血压。Animal Model:C57BL6/J male mice (8-10 weeks old) with heart failure.
Dosage:1% DMB soluble in water.
Administration:Oral gavage; 6 weeks.
Result:Reduced the plasma trimethylamine N-oxide (TMAO) levels, the cross-sectional area of LV cardiomyocytes, and the area of LV interstitial fibrosis.Decreased the expression of ANP, BNP, β-MHC, collagen Iα, collagen III and CTGF. Inhibited TNF-α, IL-6, IL-1β, p65, TGF-β and Smad3 expression.
Animal Model:Male and female ICR mice (8-weeks old).
Dosage:0.2% and 1.0% DMB soluble in water.
Administration:Oral gavage; 21 d.
Result:Showed insignificantly effect on body weight, water intake, food intake, sexual preference, anxiety, depression and memory formation. Weakened the social dominance of mice.
Animal Model:Pregnant Sprague-Dawley rats.
Dosage:1.0% DMB soluble in water.
Administration:Oral gavage; gestation period and suckling period.
Result:Increased kidney weight, plasma trimethylamine (TMA) level and acetic acid, reduced diastolic. Had significantly effect on gut microbiota composition.
体外研究：
3,3-Dimethyl-1-butanol 是月桂基二甲基磺基甜菜碱/水体系的助表面活性剂。
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