产品
编 号：F409274
分子式：C8H18ClNO2
分子量：195.69
分子式：C8H18ClNO2
分子量：195.69
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
结构图
CAS No: 62-51-1
产品详情
生物活性：
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.
体内研究：
Methacholine choride (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs.Methacholine choride (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse.Animal Model:9-week female BALB/c mice
Dosage:0.03, 0.1, 0.3, 1 mg/kg
Administration:I.v.
Result:Induced severe bronchoconstriction.
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates.
体内研究：
Methacholine choride (0.5 μg/kg plus 5 μg/kg/min for 30 min) induces bronchoconstriction in dogs.Methacholine choride (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 μg/kg; i.v.) in a a dose-dependent manner in mouse.Animal Model:9-week female BALB/c mice
Dosage:0.03, 0.1, 0.3, 1 mg/kg
Administration:I.v.
Result:Induced severe bronchoconstriction.
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