产品
编 号：F410502
分子式：C7H17NO5
分子量：195.21
分子式：C7H17NO5
分子量：195.21
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
440
In-stock
500mg
400
In-stock
结构图
CAS No: 6284-40-8
产品详情
生物活性：
Meglumine (Methylglucamine) is an orally active amino sugar derived from sorbitol. Meglumine has anti-inflammatory and antitumor activity. Meglumine is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide.
体内研究：
Meglumine (25 或 50 mM；37.5 mM, 溶解在水中口服) 在大鼠和小鼠中可减少炎症因子水平，抑制皮肤癌肿瘤生长。Meglumine (18 mM, 口服) 在 Ⅱ 型糖尿病小鼠中可改善肌肉功能、限制代谢综合征和减少糖尿病并发症。Animal Model:Sprague-Dawley rat
Dosage:25 or 50 mM
Administration:p.o., dissolve in water
Result:Reduced the isoprostane levels in rats.
Animal Model:K6/ODC transgenic mice
Dosage:37.5 mM
Administration:p.o., dissolve in water
Result:Reduced the number of skin tumors and inhibited tumor growth.
Animal Model:KK.Cg-Ay/J mice
Dosage:18 mM
Administration:p.o., in drinking water
Result:Performed better in a glucose tolerance test.Decreased their average fasting levels of glucose and triglyceride levels in both the liver and blood serum.
体外研究：
Meglumine (40 或 80 mM，24 h；50 mM, 24 h) 在 THP-1 人髓样细胞和 RAW264.7 小鼠巨噬细胞细胞中剂量依赖性降低炎症因子水平 (Elisa assay)。Meglumine (0-300 mM, 60 min) 在 C2C12 小鼠成肌细胞中剂量依赖性的增加 SNARK 的表达水平。
Meglumine (Methylglucamine) is an orally active amino sugar derived from sorbitol. Meglumine has anti-inflammatory and antitumor activity. Meglumine is often used as an excipient in active molecules and with iodinated compounds in contrast agents such as meglumine and meglumine iodide.
体内研究：
Meglumine (25 或 50 mM；37.5 mM, 溶解在水中口服) 在大鼠和小鼠中可减少炎症因子水平，抑制皮肤癌肿瘤生长。Meglumine (18 mM, 口服) 在 Ⅱ 型糖尿病小鼠中可改善肌肉功能、限制代谢综合征和减少糖尿病并发症。Animal Model:Sprague-Dawley rat
Dosage:25 or 50 mM
Administration:p.o., dissolve in water
Result:Reduced the isoprostane levels in rats.
Animal Model:K6/ODC transgenic mice
Dosage:37.5 mM
Administration:p.o., dissolve in water
Result:Reduced the number of skin tumors and inhibited tumor growth.
Animal Model:KK.Cg-Ay/J mice
Dosage:18 mM
Administration:p.o., in drinking water
Result:Performed better in a glucose tolerance test.Decreased their average fasting levels of glucose and triglyceride levels in both the liver and blood serum.
体外研究：
Meglumine (40 或 80 mM，24 h；50 mM, 24 h) 在 THP-1 人髓样细胞和 RAW264.7 小鼠巨噬细胞细胞中剂量依赖性降低炎症因子水平 (Elisa assay)。Meglumine (0-300 mM, 60 min) 在 C2C12 小鼠成肌细胞中剂量依赖性的增加 SNARK 的表达水平。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备