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编 号:F411056
分子式:C28H58
分子量:394.76
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5g
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生物活性:
Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l.

体内研究:
Octacosane (500 μg; injected at peripheral sites in relation to the original cell grafting; daily; 35 days) results in a significant delay of tumor progression with a significant antitumor effect.Animal Model:C57Bl/6 mice?with B16F10-Nex2 Cellsl
Dosage:500 μg
Administration:Injected at peripheral sites in relation to the original cell grafting; daily; 35 days
Result:Resulted in a significant delay of tumor progression with a significant antitumor effect. The survival rate of treated groups was significantly increased.

体外研究:
Octacosane (12.5-100 μg/ml; 18 h) displays strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml.
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