产品
编 号：F411923
分子式：C4H10NO5P
分子量：183.1
分子式：C4H10NO5P
分子量：183.1
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CAS No: 6323-99-5
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生物活性：
DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system.
体外研究：
DL-AP4 (500 μM) reduces the tonic inward current by closing ion channels at holding potentials of -33 mV in isolated rod bipolar cells.DL-AP4 (0.1 M; 1h) antagonizes the excitatory action of glutamate applied iontophoretically to receptors present in the locust muscle membrane.DL-AP4 (compound 2) antagonizes excitatory synapses in the lateral perforant path of the rat hippocampal slice with an apparent Kd of 2.5 μM.DL-AP4 (50 μM; 0-2 seconds) blocks the light response of a series of 10 ms 405-nm flashes, at the following strengths: 3, 10, 30, 100, 300, 990, 3000, 9900 photons μm-2.
DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system.
体外研究：
DL-AP4 (500 μM) reduces the tonic inward current by closing ion channels at holding potentials of -33 mV in isolated rod bipolar cells.DL-AP4 (0.1 M; 1h) antagonizes the excitatory action of glutamate applied iontophoretically to receptors present in the locust muscle membrane.DL-AP4 (compound 2) antagonizes excitatory synapses in the lateral perforant path of the rat hippocampal slice with an apparent Kd of 2.5 μM.DL-AP4 (50 μM; 0-2 seconds) blocks the light response of a series of 10 ms 405-nm flashes, at the following strengths: 3, 10, 30, 100, 300, 990, 3000, 9900 photons μm-2.
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