产品
编 号：F414350
分子式：C19H35NO4
分子量：341.49
分子式：C19H35NO4
分子量：341.49
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CAS No: 64054-40-6
产品详情
生物活性：
CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
体内研究：
CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion.Animal Model:Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)
Dosage:200 μg/kg body weight
Administration:Intraperitoneal injection; daily for remaining three weeks
Result:High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
体外研究：
CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM.
CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
体内研究：
CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion.Animal Model:Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)
Dosage:200 μg/kg body weight
Administration:Intraperitoneal injection; daily for remaining three weeks
Result:High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values.
体外研究：
CAY10580 (10-10000 nM; 40 min) significantly increases apical membrane abundance of AQP2 in MDCK cells at 100 to 10000 nM.
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