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编 号：F414815
分子式：C53H72N2O122+
分子量：929.14
分子式：C53H72N2O122+
分子量：929.14
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CAS No: 64228-79-1
产品详情
生物活性：
tracurium (BW-33A free acid) is a potent, competitive and non-depolarizing neuromuscular blocking agent.Atracurium also is an AChR receptor antagonist. Atracurium induces bronchoconstriction and neuromuscular blockade. Atracurium promotes astroglial differentiation.
体内研究：
Atracurium (1, 5, 10, 20, 50 mg/kg; i.v.) induces bronchoconstriction in DBA/2 and SJL mice.Atracurium (4.8 mg/kg; i.v.) induces neuromuscular blockade in rats.Animal Model:5-12 weeks, 15-20 g male mice
Dosage:1, 5, 10, 20, 50 mg/kg
Administration:I.v.
Result:Induced bronchoconstriction and Atracurium-induced airway hyperresponsiveness in DBA/2 mice was eliminated in a dose-dependent manner by pretreatment with atropine or pancuronium.
Animal Model:290 ± 30 g Male Sprague±Dawley rats (60 mg/kg heat-killed Corynebacteriumparvum for i.v.)
Dosage:4.8 mg/kg
Administration:I.v.
Result:Induced neuromuscular blockade in Corynebacteriumparvum-injected rats.
体外研究：
Atracurium (10 μM; 72 h) promotes astroglial but not neuronal differentiation in HSR040622 and HSR040821 cells.Atracurium (10 μM; 48 h) reduces tumor engraftment and increases survival of mice xenotransplanted with ex-vivo treated GSCs.Atracurium (2.4 μM; 120 min) induces a complete fade of the tetanic contraction while only slightly affected the twitch in rat extensor digitorum longus muscle cells.
tracurium (BW-33A free acid) is a potent, competitive and non-depolarizing neuromuscular blocking agent.Atracurium also is an AChR receptor antagonist. Atracurium induces bronchoconstriction and neuromuscular blockade. Atracurium promotes astroglial differentiation.
体内研究：
Atracurium (1, 5, 10, 20, 50 mg/kg; i.v.) induces bronchoconstriction in DBA/2 and SJL mice.Atracurium (4.8 mg/kg; i.v.) induces neuromuscular blockade in rats.Animal Model:5-12 weeks, 15-20 g male mice
Dosage:1, 5, 10, 20, 50 mg/kg
Administration:I.v.
Result:Induced bronchoconstriction and Atracurium-induced airway hyperresponsiveness in DBA/2 mice was eliminated in a dose-dependent manner by pretreatment with atropine or pancuronium.
Animal Model:290 ± 30 g Male Sprague±Dawley rats (60 mg/kg heat-killed Corynebacteriumparvum for i.v.)
Dosage:4.8 mg/kg
Administration:I.v.
Result:Induced neuromuscular blockade in Corynebacteriumparvum-injected rats.
体外研究：
Atracurium (10 μM; 72 h) promotes astroglial but not neuronal differentiation in HSR040622 and HSR040821 cells.Atracurium (10 μM; 48 h) reduces tumor engraftment and increases survival of mice xenotransplanted with ex-vivo treated GSCs.Atracurium (2.4 μM; 120 min) induces a complete fade of the tetanic contraction while only slightly affected the twitch in rat extensor digitorum longus muscle cells.
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