产品
编 号：F414816
分子式：C65H82N2O18S2
分子量：1243.48
分子式：C65H82N2O18S2
分子量：1243.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
528
In-stock
100mg
880
In-stock
500mg
2640
In-stock
结构图
CAS No: 64228-81-5
产品详情
生物活性：
Atracurium (BW-33A) besylate is a potent, competitive and non-depolarizing neuromuscular blocking agent. Atracurium besylate also is an AChR receptor antagonist. Atracurium besylate induces bronchoconstriction and neuromuscular blockade. Atracurium besylate promotes astroglial differentiation.
体内研究：
Atracurium besylate (1, 5, 10, 20, 50 mg/kg; i.v.) induces bronchoconstriction in DBA/2 and SJL mice.Atracurium besylate (4.8 mg/kg; i.v.) induces neuromuscular blockade in rats.Animal Model:5-12 weeks, 15-20 g male mice
Dosage:1, 5, 10, 20, 50 mg/kg
Administration:I.v.
Result:Induced bronchoconstriction and Atracurium-induced airway hyperresponsiveness in DBA/2 mice was eliminated in a dose-dependent manner by pretreatment with atropine or pancuronium.
Animal Model:290 ± 30 g Male Sprague±Dawley rats (60 mg/kg heat-killed Corynebacteriumparvum for i.v.)
Dosage:4.8 mg/kg
Administration:I.v.
Result:Induced neuromuscular blockade in Corynebacteriumparvum-injected rats.
体外研究：
Atracurium besylate (10 μM; 72 h) promotes astroglial but not neuronal differentiation in HSR040622 and HSR040821 cells.Atracurium besylate (10 μM; 48 h) reduces tumor engraftment and increases survival of mice xenotransplanted with ex-vivo treated GSCs.Atracurium besylate (2.4 μM; 120 min) induces a complete fade of the tetanic contraction while only slightly affected the twitch in rat extensor digitorum longus muscle cells.
Atracurium (BW-33A) besylate is a potent, competitive and non-depolarizing neuromuscular blocking agent. Atracurium besylate also is an AChR receptor antagonist. Atracurium besylate induces bronchoconstriction and neuromuscular blockade. Atracurium besylate promotes astroglial differentiation.
体内研究：
Atracurium besylate (1, 5, 10, 20, 50 mg/kg; i.v.) induces bronchoconstriction in DBA/2 and SJL mice.Atracurium besylate (4.8 mg/kg; i.v.) induces neuromuscular blockade in rats.Animal Model:5-12 weeks, 15-20 g male mice
Dosage:1, 5, 10, 20, 50 mg/kg
Administration:I.v.
Result:Induced bronchoconstriction and Atracurium-induced airway hyperresponsiveness in DBA/2 mice was eliminated in a dose-dependent manner by pretreatment with atropine or pancuronium.
Animal Model:290 ± 30 g Male Sprague±Dawley rats (60 mg/kg heat-killed Corynebacteriumparvum for i.v.)
Dosage:4.8 mg/kg
Administration:I.v.
Result:Induced neuromuscular blockade in Corynebacteriumparvum-injected rats.
体外研究：
Atracurium besylate (10 μM; 72 h) promotes astroglial but not neuronal differentiation in HSR040622 and HSR040821 cells.Atracurium besylate (10 μM; 48 h) reduces tumor engraftment and increases survival of mice xenotransplanted with ex-vivo treated GSCs.Atracurium besylate (2.4 μM; 120 min) induces a complete fade of the tetanic contraction while only slightly affected the twitch in rat extensor digitorum longus muscle cells.
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