产品
编 号:F414944
分子式:C11H14N2O4S
分子量:270.3
产品类型
结构图
CAS No: 64268-93-5
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产品详情
生物活性:
VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. VP-4604 exhibits significant microbial growth inhibition toward Staphylococcus aureus (ATCC 43300) with MIC of 4-8 μg/mL. VP-4604 inhibits the growth of methicillin‐resistant Staphylococcus aureus with growth inhibition >95%.
体外研究:
VP-4604 (2.5 mM, 18 hours) inhibits drug-resistant S. aureus and P. aeruginosa with growth inhibiton (%) GI >95%.VP-4604 shows low cytotoxicity with a CC50 value >118.4 mM towards HEK-293 (human embryonic kidney) ATCC CRL‐1573 and an HC10 vaule >118.4 μM towards RBC (human red blood cells) .VP-4604 (2.5 mM) is tolerated by mammalian cells (HaCaT, lymphocytes) with the inhibition growth (%) of 44.1% and >50%, respectively.