产品
编 号：F416118
分子式：C12H18N2O3S
分子量：270.35
分子式：C12H18N2O3S
分子量：270.35
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
320
In-stock
1g
400
In-stock
5g
484
In-stock
结构图
CAS No: 64-77-7
产品详情
生物活性：
Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete.
体内研究：
Tolbutamide (125 mg/kg，在日常饮食中补充 27 周) 降低非肥胖糖尿病小鼠的糖尿病发病率。Tolbutamide (100-400 mg/kg，腹腔注射，第 13 天给药 400 mg/kg; 第 10-13 天给药 100 mg/kg; 联合用药: 第 10-12 天 100 mg/kg，第 13 天 400 mg/kg) 降低孕鼠胎儿死亡。Animal Model:Non-obese-diabetic mouse
Dosage:125 mg/kg
Administration:Supplemented in daily diet for 27 weeks
Result:Showed 10 of 23 animals developed diabetes compared with 18 of 24 in the control groups.
Animal Model:Pregnant mice
Dosage:100 mg/kg, 400 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Showed a significant reduction (50 %) in the frequency of living fetuses for the group of 400 mg/kg on day 13.Had significantly fewer petechiae and more late resorptions for the group of 400 mg/kg on day 13.
体外研究：
Tolbutamide (400 μM, 24h) 与 dbcAMP 通过增加缝隙连接蛋白 43 (Cx43) 降低胶质瘤细胞增殖。Tolbutamide (0.1 μM, 1 min) 通过激活线粒体样 KATP 通道来刺激大鼠 A 细胞的胞吐。
Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete.
体内研究：
Tolbutamide (125 mg/kg，在日常饮食中补充 27 周) 降低非肥胖糖尿病小鼠的糖尿病发病率。Tolbutamide (100-400 mg/kg，腹腔注射，第 13 天给药 400 mg/kg; 第 10-13 天给药 100 mg/kg; 联合用药: 第 10-12 天 100 mg/kg，第 13 天 400 mg/kg) 降低孕鼠胎儿死亡。Animal Model:Non-obese-diabetic mouse
Dosage:125 mg/kg
Administration:Supplemented in daily diet for 27 weeks
Result:Showed 10 of 23 animals developed diabetes compared with 18 of 24 in the control groups.
Animal Model:Pregnant mice
Dosage:100 mg/kg, 400 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Showed a significant reduction (50 %) in the frequency of living fetuses for the group of 400 mg/kg on day 13.Had significantly fewer petechiae and more late resorptions for the group of 400 mg/kg on day 13.
体外研究：
Tolbutamide (400 μM, 24h) 与 dbcAMP 通过增加缝隙连接蛋白 43 (Cx43) 降低胶质瘤细胞增殖。Tolbutamide (0.1 μM, 1 min) 通过激活线粒体样 KATP 通道来刺激大鼠 A 细胞的胞吐。
产品资料
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